Zebularine (“Zeb”) Treatment of TCC in Dogs

Study details: Canine urinary bladder cancer

Species: Dogs

Tumor: Bladder cancer

Purpose of Study: Zeb is an oral medicine in a new category of cancer drugs called demethylating agents. Demethylating agents work differently than traditional cancer drugs. Traditional cancer drugs stop DNA replication or block cancer cell division by similar means. Demethylating agents reactivate genes within the cancer cells called tumor suppressor genes. In humans and dogs that do not have cancer, tumor suppressor genes are working to prevent cancer from forming and growing. In dogs and humans that do have cancer, however, the tumor suppressor genes are not working correctly. An important mechanism that keeps these genes from working properly is through the attachment of methyl groups to a specific part of the gene. Zeb and similar drugs remove the methyl groups or prevent methyl groups from attaching, thereby allowing the tumor suppressor genes to return to their normal function, i.e. stopping cancer. Zeb has been very well tolerated with few side effects at the doses being used in dogs. There are two components to this study: (1) to determine how well zeb works by itself, and (2) to determine the beneficial effects of zeb given with a traditional chemotherapy drug called carboplatin. For more information, click here.