VEGFR Ultrasound Study

Study Details:

Species: Canines

Tumor: Soft Tissue Sarcoma, Transitional Cell Carcinoma of the bladder or Thyroid Cancer

For more information: Click Here or CONTACT DR. MICHELE STEFFEY (530-752-1393) FOR INCLUSION IN THE STUDY.

Purpose of the Study The purpose of this study is to assess a novel ultrasound technique for its ability to approximate a tumors angiogenic potential.  This technique involves the intravenous injection of a contrast agent that is targeted to a specific feature (vascular endothelial growth factor receptor or VEGFR density) of highly angiogenic blood vessels in the tumor. Our goal is to use this ultrasound technique to measure VEGFR density before therapy is instituted and compare this to special VEGFR stains of biopsied tumor tissue to ensure that the ultrasound technique truly approximates angiogenesis. This may allow us to prognosticate regarding future behavior of the tumor.  In addition, we believe that this measure may act as a predictor of response to chemotherapy.