Monoclonal Antibody Therapy of Canine B-cell Lymphoma

Study Details:  Monoclonal Antibody Therapy of Canine B-cell Lymphoma

Species: Canines

Tumor: Lymphoma

Purpose of the Study: We are investigating whether an antibody that specifically targets a particular receptor on the surface of malignant B cells could be used to treat dogs with B cell (non-Hodgkin’s) lymphoma. Many types of lymphoma have this receptor on their surface at high levels, a property that makes them stand out from normal immune cells in the body. An antibody targeting this receptor (known as IMMU-114) has recently been developed and is being investigated as a possible new treatment for both humans and dogs with B cell lymphoma. We have tested this antibody in normal, healthy dogs and found that it is safe as long as it is given slowly as an intravenous infusion during an overnight hospital stay. We are now ready to begin evaluating the antibody in dogs with lymphoma so that we evaluate its potential efficacy in treating this common disease. For more information, click here.