CHOP vs. CHO Chemotherapy for Canine Multicentric Lymphoma

Study details: CHOP vs. CHO chemotherapy

Species: Dogs

Tumor: lymphomas

Purpose of Study: Combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (“CHOP”) is considered the standard of care for canine intermediate-to-high grade multicentric lymphoma. Previous therapy with prednisone is known to decrease remission duration and survival time for dogs with CHOP-treated lymphoma, likely by increasing chemotherapy drug resistance within tumor cells. It is unknown whether removal of prednisone from the CHOP protocol affects drug resistance. In this study, dogs will be randomly assigned to CHOP or CHO (CHOP without prednisone) chemotherapy protocols, and remission rate, remission duration, and survival time will be compared between treatment groups. For more information, click here.