Study Details: Effect of Carboplatin on Circulating Endothelial Cells in Dogs with Cancer.
Tumor: Various tumor types (except hemangiosarcoma).
Purpose of study: Chemotherapy typically is administered at maximally tolerated (high) doses at regular intervals, such as once every three weeks. Although the chemotherapy drug kills rapidly growing cancer cells, some normal cells (such as those in the bone marrow and intestines) are also affected and a recovery period is needed for these tissues to renew themselves. Unfortunately, this gap in treatment can allow the cancer cells time to grow as well. Research in mice and people has also shown that high-dose chemotherapy may also stimulate production of cells such as circulating endothelial cells (CECs) that likely help tumors develop a new blood supply (this process is called “angiogenesis”) and lead to further growth of the tumor. The effect of high-dose chemotherapy on CECs has not been previously evaluated in dogs. This study is being performed to determine the effect of standard doses of carboplatin chemotherapy on CECs in dogs with cancer. For more information, click here.