Canine Soft Tissue Sarcomas

Study Details:  PET-CT Imaging of Canine Tumors with 64-Copper-ATSM to Detect Areas of Low Tumor Oxygen Level

Species: Canines

Tumor: Soft tissue Sarcoma

Purpose of study:  Tumors with areas of low oxygen level are more resistant to treatment by either radiation or chemotherapy. Those areas may also harbor primitive tumor stem cells that can cause a tumor to recur after therapy. The primary objective of this study is to perform and validate a new noninvasive diagnostic imaging method for imaging areas of a tumor with low oxygen, called a PET/CT scan. PET stands for Positron Emission Tomography, which will use a radioactively labeled tracer (64Copper-ATSM) that localizes to those areas of a tumor with low oxygen. CT is computed tomography, which allows us to visualize the anatomy. After PET/CT imaging, we will then obtain a biopsy specimen of that same area to study the characteristics of that tumor region. This information will contribute to the development of new and better ways to identify resistant tumor regions and treat those areas more appropriately, with the ultimate goal being to improve cancer treatment. The PET/CT scan may also help us better stage your pet’s cancer by looking for potential areas of metastasis (spread of cancer). For more information, click here.