Canine Osteosarcoma Study

Study Details: Canine Osteosarcoma Study

Species: Canines

Tumor: Osteosarcoma

Purpose of study: In this study, dogs diagnosed with osteosarcoma are invited to participate. The participant patient will be treated with amputation, IL-12 and standard chemotherapy treatment. IL-12 administration via electroporation will be performed 2-7 days prior to and 2-7 days post surgery. If you are not satisfied with the outcome, you can withdraw your pet from the clinical trial anytime. The participant patients will be anesthetized through LSU-SVM anesthesia service for performing the treatment, including injection of the immune stimulator via electroporation. Needles will be inserted into tumors for injection and electroporation. The electroporation lasts for less than one second and the whole procedure last for less than 5 minutes once dogs are under anesthesia. A total of two IL-12 administrations via electroporation will be performed. Prior to both the first and the second IL-12 administration, blood will be drawn for CBC, serum chemistry profile, and cytokine profile analysis. A follow-up check will be performed one week after the second treatment. Carboplatin (a standard chemotherapy drug) will be administered every 3 weeks, and a total of five doses will be administered. A follow-up recheck will be performed every other month after completion of the chemotherapy protocol.

For further information on this study contact: Dr Keijiro Shiomitsu (225) 578-9600 Fax: (225) 578-9559 E-mail: or Dr Tracy Gieger Phone: (225) 578-9600 Fax: (225) 578-9559 E-mail: